The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered "undruggable", and several projects have entered clinical evaluation worldwide.
Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer....
What are Liposomes?
Liposome is an artificial carrier membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends to the air, and after agitation, a spherical liposome of bilayer lipid molecules is formed. This bilayer structure is the same as the skin cell membrane structure, which helps the skin to...
Contract research organizations and boutique biotech groups have developed pomalidomide derivatives into the most widely used plug-and-play CRBN recruiters: the scaffold provides a clean departure point, gram-scale commercial availability and a largely 'greyed' intellectual-property landscape. Stocking a freezer full of pre-functionalized C4- and C5-linker congeners (acetamides,...
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