Protein fermentation describes the microbial population's controlled breakdown and build-up of nitrogenous compounds under specific redox potential, pH balance and substrate limitation constraints. The process generally begins with the extracellular degradation of high molecular weight proteins. Protein hydrolysis by microbial aspartic proteases (fungi) or metalloproteases (bacteria)...
ADC manufacturing is an emerging and highly complex biopharmaceutical technology that has attracted significant attention from innovative biopharmaceutical companies and CDMO procurement professionals. Antibody–drug conjugates (ADCs) are a class of precision therapeutics in which highly potent small-molecule cytotoxic drugs are chemically linked to tumor-targeting antibodies. The design...
In the field of vaccine development, peptide vaccines, as an emerging vaccine platform, have gradually become the focus of research due to their advantages such as high safety, strong targeting, and customizability. However, despite the great potential shown by peptide vaccines, stability and immunogenicity remain two major challenges in their application process. Issues such as peptide...
Transcriptomics Definition
Transcriptomics is the study of the overall expression of all transcribed RNAs (mRNAs, non-coding RNAs including siRNAs, miRNAs, lincRNAs, etc.) and their regulation in living organisms. It comprehensively analyzes and identifies transcripts in cells or tissues through high-throughput sequencing technology, and quantitatively and functionally analyzes them through...
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered "undruggable", and several projects have entered clinical evaluation worldwide.
Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer....
What are Liposomes?
Liposome is an artificial carrier membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends to the air, and after agitation, a spherical liposome of bilayer lipid molecules is formed. This bilayer structure is the same as the skin cell membrane structure, which helps the skin to...
Contract research organizations and boutique biotech groups have developed pomalidomide derivatives into the most widely used plug-and-play CRBN recruiters: the scaffold provides a clean departure point, gram-scale commercial availability and a largely 'greyed' intellectual-property landscape. Stocking a freezer full of pre-functionalized C4- and C5-linker congeners (acetamides,...
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